<?xml version="1.0" encoding="UTF-8" standalone="no"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="systematic-review" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">Open Res Europe</journal-id>
            <journal-title-group>
                <journal-title>Open Research Europe</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2732-5121</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/openreseurope.14280.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Systematic Review</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Co-creation methodology with Smart technologies in Health and well-being to enable communication between isolated and disperse small communities: a literature review</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 1 approved, 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>RAMOS</surname>
                        <given-names>Victoria</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-8776-4489</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <collab>MELTIC partners</collab>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>de San Pedro</surname>
                        <given-names>Iris</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Casado</surname>
                        <given-names>Elvira</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Santacruz</surname>
                        <given-names>Esmeralda</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-4249-3179</uri>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Hern&#xE1;ndez</surname>
                        <given-names>Coral</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-6218-8991</uri>
                    <xref ref-type="aff" rid="a4">4</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Alcoceda</surname>
                        <given-names>Jose A.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <xref ref-type="aff" rid="a4">4</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>de Tena-Davila</surname>
                        <given-names>M.Jose</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Burgos</surname>
                        <given-names>Alfredo</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Perez de la Camara</surname>
                        <given-names>Santiago</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Marina-Boillos</surname>
                        <given-names>Pablo</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-3255-9311</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Pascual</surname>
                        <given-names>Mario</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Telemedicine and Digital Health Research Unit, Instituto de Salud Carlos III, Madrid, Madrid, 28029, Spain</aff>
                <aff id="a2">
                    <label>2</label>Instituto de Salud Carlos III, Madrid, 28029, Spain</aff>
                <aff id="a3">
                    <label>3</label>Universidad Castilla la Mancha, Toledo, Spain</aff>
                <aff id="a4">
                    <label>4</label>Universidad Complutense, Madrid, Spain</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:vramos@isciii.es">vramos@isciii.es</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>25</day>
                <month>7</month><year>2022</year>
            </pub-date>
            <pub-date pub-type="collection"><year>2022</year>
            </pub-date><volume>2</volume>
            <elocation-id>2</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>18</day>
                    <month>7</month><year>2022</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#xA9; 2022 RAMOS V et al.</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://open-research-europe.ec.europa.eu/articles/2-2/pdf"/>
            <abstract>
                <p>
                    <bold>Objective:</bold> The objective is to determine reported cases of co-creation methodology about the use of smart technologies in public spaces in order to create new forms of social interactions and practices, which in turn creates new socio-spatial relations and promotes interactions and communication between isolated and disperse communities.</p>
                <p>
                    <bold>Methods:</bold> The literature published in the last 5 years (2016&#x2013;2020) has been reviewed. Searches on Co-creation methodology and ICTs in Health and Biomedicine, on topics such as interaction among users, ICT and social behavior, spatial analyses, planning methodologies and public involvement, on-line gaming, self&#x2010;learning, and the prevention of risky habbits were made manually.</p>
                <p>
                    <bold>Results:</bold> Search strategies developed through electronic databases and manual search identified a total of 180 references, included in the supplementary material. They have been divided by the technologies used in the studies, co-creation methodology, and according to the type of socio-medical application. This research highlights the penetration of ICT in social and healthcare environments and clearly demonstrates the high number of publications that have come out over recent years and a lack of publications that evaluate co-creation methodology in this field.</p>
                <p>
                    <bold>Conclusions</bold>:  Most of the papers included only partially cover the subject matter of ICT in Health and Biomedicine and how to use smart technologies to transform public spaces in small communities into people-friendly human environments. The research carried out for this paper clearly demonstrates the high number of publications concerning technology assessment. However, there is a distinct lack of publications that evaluate co-creation methodology.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Co-creation</kwd>
                <kwd>smart technologies</kwd>
                <kwd>health</kwd>
                <kwd>wellbeing</kwd>
                <kwd>small communities</kwd>
                <kwd>open-science</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1" xlink:href="http://dx.doi.org/10.13039/100010661">
                    <funding-source>Horizon 2020 Framework Programme</funding-source>
                    <award-id>741527</award-id>
                </award-group>
                <funding-statement>This research was financially supported by the European Union&#x2019;s Horizon 2020 research and innovation programme under the grant agreement No 741527 (project ORION).</funding-statement>
                <funding-statement>
                    <italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
                </funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>Thank you very much for reviewers&#x2019; contributions-most of them has been incorporated. The article has been enriched with these suggestions: 
                    <list list-type="bullet">
                        <list-item>
                            <p>The term &#x2018;Telemedicine&#x2019; was not included so as not to move the object of the work towards the health side, nor the more technological aspects of the near future such as the 'metaverse'. In accordance with this sense of work, the interesting suggestion of changing the word &#x2018;patient&#x2019; for &#x2018;subjects&#x2019; or &#x2018;individuals&#x2019; has been taken into account.</p>
                        </list-item>
                        <list-item>
                            <p>The meaning of Information and Communications Technologies (ICT) and the shortcomings of current studies have been clarified.</p>
                        </list-item>
                        <list-item>
                            <p>The English writing was improved.</p>
                        </list-item>
                        <list-item>
                            <p>The suggestions in Tables have been clarified, as well as completing the title of Table 3.</p>
                        </list-item>
                        <list-item>
                            <p>Figures have been renumbered so that they appear in order of appearance in the text. The term &#x2018;meta-analysis&#x2019; has been removed from Figure 1.</p>
                        </list-item>
                        <list-item>
                            <p>Annex 1 has been included in the Extended data, with all 180 articles. That Annex had been lost in the previous version.</p>
                        </list-item>
                        <list-item>
                            <p>It is suggested that more studies are needed in these specific areas by reviewers and authors agree and included that comment.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
        </notes>
    </front>
    <body>
        <sec>
            <title>Plain language summary</title>
            <p>In co-creative methodology, all teams are involved and have influence throughout the project lifecycle: from planning, to implementation, to dissemination in order to identify topics and players of interest and  they can be involved in research activity to share their interests and values and generate new ideas, concepts, products, or projects. The use of smart technologies in public spaces is increasingly creating new forms of social interactions and practices, which in turn creates new socio-spatial relations and promotes interactions and communication between isolated and disperse communities. This results in the need to re-think social practices and the use of public spaces which could also have an impact on the development of Information and Communication Technologies (ICT) and their devices.</p>
            <p>By means of this methodology are seeked to (1) obtain contributions by users, (2) produce a reference document with all these contributions. The aim of this review was to determine already reported cases of co-creation methodology about the use of smart technologies in public spaces, new forms of social interactions and practices, interactions and communication between isolated and disperse communities, and the existence of a digital divide.</p>
            <p>This research identifies relevant studies, which exemplify the penetration of ICT in social and healthcare environments in real workflows. Most of the papers included only partially cover the subject matter &#x201C;ICT in Health and Biomedicine and how to use smart technologies to transform public spaces in small communities into people-friendly human environments&#x201D;. It can be stated that ICT in social and healthcare settings will play a key role in fostering ubiquitous and proactive health and healthcare services in the future in order to promote healthy habits or to change high-risk behavior, using non-biased Information, maintaining anonymity and avoiding stigmatization.</p>
        </sec>
        <sec sec-type="intro">
            <title>Introduction</title>
            <p>In co-creative methodology, all teams are involved and have influence throughout the project lifecycle: from planning, to implementation, to dissemination in order to identify topics and players of interest and  they can be involved in research activity to share their interests and values and generate new ideas, concepts, products, or projects within the wide group of members formed by government entities, funders, regulators, educators, charities, civil societies, patient groups and citizens.</p>
            <p>The use of smart technologies in public spaces is increasingly creating new forms of social interactions and practices, which in turn creates new socio-spatial relations and promotes interactions and communication between isolated and disperse communities. These new uses and environments results in the need to re-think social practices and the use of public spaces which could also have an impact on the development of Information and Communications Technologies (ICT) and their devices. The intertwining of real and virtual worlds also opens up new ways of advancing knowledge, gathering and interpreting data, and disseminating the acquired knowledge. ICTs permeate our daily lives and  connect with diverse European Policy challenges such as depopulation, health, active aging, education, youth, and climate change, with the aim of identifying current and future problems in order to innovate the use of existing public spaces and/or build new ones. We are experiencing a digital era of real-time transmission of data and immense computing power, specially subjects or subjects&#x2019; environments that use or form part of an ICT system
                <sup>
                    <xref ref-type="bibr" rid="ref-1">1</xref>
                </sup>.</p>
            <p>Long-term experiences and analysis of this applications do not yet exist. Due to the rapid development and application of new technologies there is a permanent need to monitor and support the work of ICT researchers, urban designers and social agents, and an assessment of usability is needed
                <sup>
                    <xref ref-type="bibr" rid="ref-2">2</xref>
                </sup>. It is necessary to point out that the use of smart technologies in public spaces is increasingly creating new forms of social interactions and practices, as well as creating new socio-spatial relations that promote interactions and communication between isolated and disperse communities
                <sup>
                    <xref ref-type="bibr" rid="ref-3">3</xref>,
                    <xref ref-type="bibr" rid="ref-4">4</xref>
                </sup>. This result in the need to re-think social practices and the use of public spaces, which could also have an impact on the development of ICTs and their devices: living, caring, and acting
                <sup>
                    <xref ref-type="bibr" rid="ref-5">5</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>.</p>
            <p>The dialogue and connection between people (as users) with real and virtual worlds also open up new requirements in advanced knowledge, not only in new ways of gathering information, but also in how to interpret the data. Also, there is an additional need to manage and disseminate the acquired knowledge, analyse the current use and developments in electronics, information and telecommunications and the relevance they have on their daily lives, with almost every day something new being aggregated. This methodology seeks contributions by users, and produces a reference document with all these contributions. The aim of this review was to determine already reported cases of co-creation methodology about the use of smart technologies in public spaces in order to create new forms of social interactions and practices, which in turn creates new socio-spatial relations and promotes interactions and communication between isolated and disperse communities.</p>
        </sec>
        <sec sec-type="methods">
            <title>Methods</title>
            <sec>
                <title>Search strategy</title>
                <p>A digitalized literature search was conducted on Medline, the Cochrane Library, WOS, SCOPUS, and other sources not included in PubMed: MDPI, IEEE Xplore and Google Scholar in order to identify relevant articles published between 2016 and 2020. To obtain effective results, the keywords used in searches were a combination of &#x201C;co-creation&#x201C;AND(&#x201D;telemedicine&#x201D;OR&#x201D;smartphone&#x201D;OR&#x201D;mobile application (app)&#x201D;OR &#x201C;Internet&#x201D;OR&#x201D;mHealth&#x201D;OR&#x201D; eHealth&#x201D;OR&#x201D;Internet of Things&#x201D;OR&#x201D; IoT&#x201D;)AND(&#x201C;relapse prevention&#x201D; OR &#x201C;substances Use Disorder&#x201D; OR &#x201C;behavioural intervention&#x201D; OR &#x201C;rural treatment&#x201D;OR &#x201C;prevention&#x201D;OR &#x201C;rehabilitation&#x201D;OR &#x201C;harmful habits&#x201D;OR &#x201C;risk reduction behavior&#x201D;). The keywords used to search articles were a combination of the previous ones. The systematic reviews that were found initially have then been used to identify additional relevant studies. The absence of homogeneous criteria to choose keywords to describe their papers may have led to an unwanted consequence: that an indeterminate number of papers may have been omitted by search engines.</p>
            </sec>
            <sec>
                <title>Inclusion and exclusion criteria</title>
                <p>The criteria for inclusion required that the studies: (1) deal with individuals or individuals&#x2019; environments that use or form part of an ICT system, (2) have an assessment of  usability (3) be published in English (4) have Open Access. No restrictions were imposed on the quality of the study design. We have excluded editorials, letters, opinion papers, and studies that deal with questionaries, health management, data protection, ethical and legal aspects, or that only carry technical descriptions. We have also excluded those studies related to hospital or specialty care. In 
                    <xref ref-type="table" rid="T1">Table 1</xref> are presented inclusion and exclusion criteria.</p>
                <table-wrap id="T1" orientation="portrait" position="anchor">
                    <label>Table 1. </label>
                    <caption>
                        <title>Inclusion and exclusion criteria.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Variables</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Inclusion criteria</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Selected articles</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Use of technologies in projects, activities and initiatives:
                                    <break/>That include aspects of interaction among users, ICT and social behavior
                                    <break/>For spatial analyses, planning methodologies and public involvement
                                    <break/>On-line games</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Type</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Scientific papers and reviews</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Population</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">General population, patients, workers, young adults, adolescents, elderly people</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Publications date</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">From 2016</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Language</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">English</td>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Variables</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Exclusion criteria</th>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Exclusion criteria</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Not adjusted to inclusion criteria. Editorial, letters and opinion papers. </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Different data base</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Duplicates or previous study ampliation</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Application</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Hospital care or speciality care as well as those studies which deal with questionaire, health management, 
                                    <break/>data protection, ethical and legal aspects, only technical descriptions</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Results</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Questioner</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Not obtained 
                                    <break/>articles</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Previous asking</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec>
                <title>Data synthesis</title>
                <p>Two authors independently reviewed the selected papers by reading the abstracts in order to decide whether those papers should be read in their entirety and discuss limitations at study and outcome level (e.g., risk of bias), and at review-level (e.g., incomplete retrieval of identified research, reporting bias). Once this initial study was carried out, another filter was added to avoid duplication or redundant material. For each study, a checklist was used to classify the type of paper, together with a form that included the main data or the study (reference, year, objectives, results, etc.) as is shown in 
                    <xref ref-type="table" rid="T2">Table 2</xref>.</p>
                <table-wrap id="T2" orientation="portrait" position="anchor">
                    <label>Table 2. </label>
                    <caption>
                        <title>Check list to classify the studies.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">REFERENCE OF THE STUDY (PMID, ISSN)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Authors
                                    <break/>Year of publication and journal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">REFERENCE AND DESIGN OF THE STUDY</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Objective
                                    <break/>Patients or patients&#x2019; environments that use or form part of an ITC system
                                    <break/>Objective of the study</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">RESULTS ON APPLICATIONS AREAS IN TERMS OF ICT</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Value measured
                                    <break/>Result</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">RESULTS ON USERS</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Value measured
                                    <break/>Result</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">CONCLUSIONS OF THE AUTHORS</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">COMMENTS</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>Other systematic reviews that had been previously carried out by different authors were also very useful in identifying and including relevant studies that had not been initially found by search engines. They have been divided by the technologies used in the studies, and according to the type of socio-medical application.</p>
                <p>Annex 1 (DOI: 
                    <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.4321/repisalud.14692">10.4321/repisalud.14692</ext-link>) shows the papers that were included. The quality of the studies was assessed following the recommendations by the Spanish Healthcare Technology Evaluation Agency
                    <sup>
                        <xref ref-type="bibr" rid="ref-8">8</xref>
                    </sup>. The evaluation was reached via a questionnaire specifically designed for this purpose, based on items such as the sample size, description and conditions of the study presented in 
                    <xref ref-type="table" rid="T3">Table 3</xref>. The choice of these items was based on quality studies found in other reviews and adapted to the current review.</p>
                <table-wrap id="T3" orientation="portrait" position="anchor">
                    <label>Table 3. </label>
                    <caption>
                        <title>Checklist to evaluate the papers quality.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Sample</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Is the sample size appropriate?
                                    <break/>Is a clear description of the tests specified?
                                    <break/>Is the sample representative?</td>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Tests</th>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Are the conditions of the study specified?
                                    <break/>In the case of social users, are the types of patient&#x2019;s environment specified, together with their importance?
                                    <break/>In case of technological applications, is it specified if there is temporary or permanent application?
                                    <break/>Are the conditions of the evaluation specified?</td>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Results evaluation </th>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Is there a correlation between the different studies classified in the same sections?</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <p>Search strategies developed through electronic databases and manual searches identified a total of 803 references. After eliminating duplicates and other inaccurate results, 623 were excluded, leaving a total of 180 to consider, as is showed in 
                <xref ref-type="fig" rid="f1">Figure 1</xref>.</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>Study selection process.</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://openreseurope-files.f1000.com/manuscripts/16167/bf0b7035-c12c-467c-ae95-ee93a57cb4ad_figure1.gif"/>
            </fig>
            <sec>
                <title>Characteristics of included studies</title>
                <p>Although most of the papers collected only partially cover the subject matter, the research carried out for this document clearly demonstrates the high number of publications that have come out over recent years. The last 5 years were chosen to obtain a more accurate view of the technology currently available and the frequency of its use.</p>
            </sec>
            <sec>
                <title>Studies on technologies</title>
                <p>The technology that is currently available and frequently used is presented in 
                    <xref ref-type="fig" rid="f2">Figure 2</xref>. Technologies that provide useful help to patients, healthcare professionals, caregivers, men, women, workers, general public, children, adolescents, in the studied environments.</p>
            </sec>
            <sec>
                <title>Quality evaluation</title>
                <p>On the whole, the evaluation of the methodological quality of studies has been a very difficult task because of the heterogeneity of the papers included in the review. This is due to the fact that there is a lack of published papers about co-creation methodology where most of the papers included only partially cover the subject matter, and in some of the cases, the sample size was not large enough.</p>
            </sec>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>This research identifies relevant studies which highlight the penetration of ICT in social and healthcare environments. Most of the papers included only partially the items considered, on the one hand the item &#x201C;ICT in Health and Biomedicine&#x201D; and in the other hand &#x201C;how to use smart technologies to transform public spaces in small communities into people-friendly human environments&#x201D;, promoting interactions and communication between isolated and disperse communities are scarce.</p>
            <p>As 
                <xref ref-type="fig" rid="f2">Figure 2</xref> and 
                <xref ref-type="fig" rid="f3">Figure 3</xref> shows, the number of papers does not seem to have increased significantly since 2016.  The 180 papers finally included were classified into 4 categories taking into account linkage with IT means and social categories: 1. Behaviour (risk), 2. Substances (use and abuse of unhealthy), 3. Online gaming and 4. Education.</p>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>Figure 2. </label>
                <caption>
                    <title>Applications Areas in terms of ICT (Npapers: 180).</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://openreseurope-files.f1000.com/manuscripts/16167/bf0b7035-c12c-467c-ae95-ee93a57cb4ad_figure2.gif"/>
            </fig>
            <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                <label>Figure 3. </label>
                <caption>
                    <title>Papers that mention 4 social categories from 2016 to 2020 (Npapers: 180).</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://openreseurope-files.f1000.com/manuscripts/16167/bf0b7035-c12c-467c-ae95-ee93a57cb4ad_figure3.gif"/>
            </fig>
            <p>More than half of publications grouped under category 1. &#x201C;Behaviour&#x201D; refer to the use of technologies to promote healthy habits or how to change behaviour classified as risky. Participants in several works also expressed the importance of having non-judgmental information and the possibility of maintaining anonymity to avoid stigmatization [38], [76], [81], [97], [126], [171]. There is a great potential of co-creation methodology involving in the development of apps from the early years right up to old age [20], [22], [23], [27]-[30], [32], [34], [36],  [45], [52] - [54], [57], [60], [62] - [65], [68] - [71], [73], [74], [76], [77] by means of smartphone and by means of Web Platform [104] - [110], [113], [117],  [120], [124], [128],  [131], [135], [137], [138],  [140],  [149], [151], [154], [155], [158], [161], [167], [178], [180], [185].  Another described aspect is the possibility of cultural adaptation to evidence-based Western behaviour therapies towards a better prevention and treatment of syndromes and illness in different communities through the use and support of smartphones [31], [33], [47], [50], [57], [76], [79], and also support by means of Web platform [102], [107], [109], [114], [117], [123], [139], [145], [147], [149], [155], [159]. </p>
            <sec>
                <title>Studies on co-creation</title>
                <p>The research carried out for this paper clearly demonstrates the high number of publications concerning technology assessment. However, there is a distinct lack of publications that evaluate co-creation methodology. These can be specially observed in references 
                    <xref ref-type="bibr" rid="ref-1">1</xref> and 
                    <xref ref-type="bibr" rid="ref-2">2</xref>, in relation with child obesity and heart diseases.</p>
                <p>The number of articles focusing on rural populations or regions with a disperse population can only be found in references 
                    <xref ref-type="bibr" rid="ref-3">3</xref>, 
                    <xref ref-type="bibr" rid="ref-4">4</xref> and 
                    <xref ref-type="bibr" rid="ref-5">5</xref>. This work highlights the studies carried out on minority populations or those living in marginal conditions or depressed areas
                    <sup>
                        <xref ref-type="bibr" rid="ref-6">6</xref>
                    </sup> and on the existence of the digital divide presented in 
                    <xref ref-type="bibr" rid="ref-7">7</xref>.</p>
            </sec>
            <sec>
                <title>Studies on technologies</title>
                <p>Six ICT Technologies for tracking and monitoring have been found and these are reflected in 
                    <xref ref-type="fig" rid="f2">Figure 2</xref> that shows that the two categories, WEB platforms and Smartphone applications (APP), are most highly represented categories appear in 146 papers. The papers confirmed the consolidation of WEB platforms and Smartphones (APPs) in comparison to the other technological options over the last 5 years.</p>
                <p>It can be stated that smartphone-based interventions in social and health care settings play a key role in fostering the ubiquitous and proactive health oversight and healthcare services of the future, whilst having the potential to reach a high level of the population, complementing what is available on the Internet. Nevertheless, few papers show that access through apps guarantees their usage, or indeed assess whether using a smartphone application is effective in decreasing substance use.</p>
                <p>This review founded significant efforts dedicated to the dissemination of Internet-based interventions for prevention, treatment, and management of different disorders. The effects that different recruitment channels and access routes may have on the composition of the sample and on the use of the intervention should also be considered.</p>
                <p>Regarding the general population and the use of smartphone, related to the focus given to the new care models that tend to be addressed in m-Health, we are witnessing:</p>
                <p>a) An increasing interest in the health of young subjects: in particular, recently, special attention has been focused to the new forms of addiction that have been caused by mobile phone technologies</p>
                <p>b) The creation of Apps for a remote asynchronous self-therapy based on Virtual Reality (VR) and Augmented Reality (AR)</p>
                <p>c) The creation of Apps for self-awareness and empowerment with regards to the correct use of the smartphone, for instance, Apps that provide information on the time spent  using different smartphone applications and</p>
                <p>d) An increasing interest in the design and assessment of care models with a high technological content that provide psychological therapy to young subjects using the technologies and tools that they are familiar with.</p>
                <p>Some works study the social evaluation of the &#x201C;digital divide&#x201D;, also revealed in the current COVID-19 pandemic, an aspect that conditions significantly interventions based on mobile, computer and Internet use in depressed areas [6] and [7] and also in [65], [96], [108],  Possible reasons are that it is not practical to deliver those interventions to the community &#x201C;
                    <italic toggle="yes">en masse&#x201D;</italic> due to limited health care resources and availability of evidence-based interventions and practicing clinicians, especially in rural areas.</p>
                <p>An evaluation study of gaming disorders, carried out in order to mitigate symptoms of Internet gaming disorders and risky mobile or online behaviour, and in bolstering emotional well-being. Given the high level of diffusion of ICTs among young people and adolescents, interventions are also proposed to them but also focus on their parents with substance abuse or mental health issues.</p>
            </sec>
        </sec>
        <sec sec-type="conclusions">
            <title>Conclusion</title>
            <p>This research identifies relevant studies, which exemplify the penetration of ICT in social and healthcare environments in real workflows. Most of the papers included only partially cover the subject matter &#x201C;ICT in Health and Biomedicine and how to use smart technologies to transform public spaces in small communities into people-friendly human environments&#x201D;. There is a distinct lack of publications that evaluate co-creation methodology, that is only observed in references 
                <xref ref-type="bibr" rid="ref-1">1</xref> and 
                <xref ref-type="bibr" rid="ref-2">2</xref>, in relation to child obesity and heart disease.</p>
            <p>After reviewing the different studies, it can be stated that ICT in social and healthcare settings will play a key role in fostering ubiquitous and proactive health and healthcare services in the future.</p>
            <p>Future of ICT in Health and Biomedicine are likely to require an even greater amount of data derived from a multitude of different sources and a higher processing effort. At the same time, new social and health care environments should incorporate the use of technologies to promote healthy habits or to change high-risk behavior, using non-biased information, maintaining anonymity and avoiding stigmatization. There is great potential for health promotion practitioners in the area of app development in order to promote healthy behavior through all stages of life, with the possibility of cultural adaptation, as well as helping to fight against depopulation in rural areas.</p>
            <p>The fact that the most studied technologies are Web platforms and Smartphone (APPs), as shown in 
                <xref ref-type="fig" rid="f2">Figure 2</xref>, and that the percentage of studies dedicated to the assessment of the other four technologies is low, confirms the consolidation of Web platforms and Smartphones (APPs) in comparison with the other technological options over the last 5 years.</p>
            <p>The use of ICT in social and healthcare environments provide a lot of benefits and an important advance in the transformation of public spaces, whilst also promoting interaction and communication between isolated and disperse communities, improving the efficiency, quality, equity, interactions and communication between isolated and disperse communities.</p>
            <p>However, these successful factors may be accompanied by drawbacks in the assessment of co-creation methodology.  It has been considered interesting to highlight rural populations or regions with a disperse population, marginal conditions, depressed areas and the existence of a digital divide. The study of these critical factors can guide not only promotion, but also prevention in social and healthcare applications.</p>
        </sec>
        <sec>
            <title>Data availability</title>
            <sec>
                <title>Underlying data</title>
                <p>All data underlying the results are available as part of the article and no additional source data are required.</p>
            </sec>
            <sec>
                <title>Extended data</title>
                <p>ANNEX 1. Suplementary Material. [
                    <ext-link ext-link-type="uri" xlink:href="https://repisalud.isciii.es/handle/20.500.12105/14692">10.4321/repisalud.14692</ext-link>].</p>
                <p>This project contains the following underlying data:</p>
                <list list-type="bullet">
                    <list-item>
                        <p>Suplementary Material. Access in: 
                            <ext-link ext-link-type="uri" xlink:href="http://hdl.handle.net/20.500.12105/14692">http://hdl.handle.net/20.500.12105/14692</ext-link>
                        </p>
                    </list-item>
                </list>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">Creative Commons Zero &#x201C;No rights reserved&#x201D; data waiver</ext-link> (CC0 1.0 Public domain dedication).</p>
            </sec>
            <sec>
                <title>Reporting guidelines</title>
                <p>Repisalud: PRISMA checklist, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.4321/repisalud.13489">https://doi.org/10.4321/repisalud.13489</ext-link>.</p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
    </body>
    <back>
        <ack>
            <title>Acknowledgments</title>
            <p>The authors would like to thank the Stakeholders participants for having understood the interest of this study. An earlier version of this article can be found on 
                <ext-link ext-link-type="uri" xlink:href="https://www.isciii.es/QuienesSomos/CentrosPropios/UITES/Documents/D2-Literature%20review%20reviewed.pdf?">MELTIC project Website</ext-link>.</p>
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        <front-stub>
            <article-id pub-id-type="doi">10.21956/openreseurope.16167.r29756</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Florez-Garcia</surname>
                        <given-names>Victor Alfonso</given-names>
                    </name>
                    <xref ref-type="aff" rid="r29756a1">1</xref>
                    <xref ref-type="aff" rid="r29756a2">2</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-1548-623X</uri>
                </contrib>
                <aff id="r29756a1">
                    <label>1</label>Department of Public Health, Universidad del Norte, Barranquilla, Colombia</aff>
                <aff id="r29756a2">
                    <label>2</label>Joseph&#xA0;J.&#xA0;Zilber&#xA0;School&#xA0;of&#xA0;Public&#xA0;Health, University&#xA0;of&#xA0;Wisconsin, Milwaukee, WI, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>11</day>
                <month>8</month><year>2022</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#xA9; 2022 Florez-Garcia VA</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport29756" related-article-type="peer-reviewed-article" xlink:href="10.12688/openreseurope.14280.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Thank you for your previous response. Here are some additional comments:</p>
            <p> </p>
            <p> Please, check the manuscript carefully. There are spelling mistakes (e.g: behaviour, check list, disperse, etc).</p>
            <p> Citing reviewers that applied the process (e.g: Two authors independently reviewed (VR, EC))</p>
            <p> Table 3 is the checklist to evaluate the quality of the papers. However, it is not clear whether this procedure impacts the whole manuscript. Could you clarify how this evaluation was carried out? Also, is there any final evaluation for every article like high, medium, and high risk of bias? How many of these articles have a high risk of bias or poor quality?</p>
            <p> I strongly suggest that the discussion section will be improved. Currently, this section is the result section, not a real discussion.</p>
            <p> For figure #1, add chart legend (e.g, RRSS stands for&#x2026;)</p>
            <p> I suggest expanding the information inside the articles you discussed. Thus, sentences like &#x201C;These can be specially observed in references 1 and 2, in relation with child obesity and heart diseases.&#x201D; I would mention something about every paper, then cite them. Also, I would suggest improving the writing style. Thus, I would suggest changing "The number of articles focusing on rural populations or regions with a disperse population can only be found in references 3, 4, and 5.&#x201D; to say, "We identified few articles focusing on rural populations or regions with a disperse population (3-5)." This same style must be kept in the manuscript. The idea here is that the audience must have all the elements inside the paragraph.</p>
            <p> I would suggest increasing the number of references. This would show a comprehensive analysis of the subject matter.</p>
            <p>Are the rationale for, and objectives of, the Systematic Review clearly stated?</p>
            <p>Partly</p>
            <p>Is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are sufficient details of the methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results presented in the review?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Epidemiology, Public Health</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment3466-29756">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>RAMOS</surname>
                            <given-names>Victoria</given-names>
                        </name>
                        <aff>Instituto de Salud Carlos III, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>16</day>
                    <month>8</month><year>2022</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thank you for your contributions. Reviewers were VR and ISP.&#xA0; The problem with the quality are due to the disparity between articles. It is a topic with low evaluation and the reviewers articles are of very different approaches. Agree with extension of the discussion.</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report29755">
        <front-stub>
            <article-id pub-id-type="doi">10.21956/openreseurope.16167.r29755</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Fernandez-Martin</surname>
                        <given-names>Juan</given-names>
                    </name>
                    <xref ref-type="aff" rid="r29755a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r29755a1">
                    <label>1</label>Department&#xA0;of&#xA0;Computer&#xA0;Science&#xA0;and&#xA0;Artificial&#xA0;Intelligence,&#xA0;School&#xA0;of&#xA0;Technology&#xA0;and&#xA0;Telecommunications&#xA0;Engineering, University&#xA0;of&#xA0;Granada, Granada, Spain</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>26</day>
                <month>7</month><year>2022</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#xA9; 2022 Fernandez-Martin J</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport29755" related-article-type="peer-reviewed-article" xlink:href="10.12688/openreseurope.14280.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This paper aims to review published cases of co-creation methodology on the use of smart technologies in public spaces, new forms of social interactions, practices, and communication between isolated and dispersed communities, and the existence of a digital divide. The authors have reviewed and improved the first version, correcting the shortcomings of the paper.</p>
            <p> </p>
            <p> This article is somehow too ambitious because its scope includes behaviour, abuse of substances, online gaming and education. Even so, it is interesting for professionals working in these areas and searching to learn about the possibilities of new technologies in health promotion. More studies in those specific areas are needed.</p>
            <p>Are the rationale for, and objectives of, the Systematic Review clearly stated?</p>
            <p>Yes</p>
            <p>Is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are sufficient details of the methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results presented in the review?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report29495">
        <front-stub>
            <article-id pub-id-type="doi">10.21956/openreseurope.15405.r29495</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Florez-Garcia</surname>
                        <given-names>Victor Alfonso</given-names>
                    </name>
                    <xref ref-type="aff" rid="r29495a1">1</xref>
                    <xref ref-type="aff" rid="r29495a2">2</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-1548-623X</uri>
                </contrib>
                <aff id="r29495a1">
                    <label>1</label>Department of Public Health, Universidad del Norte, Barranquilla, Colombia</aff>
                <aff id="r29495a2">
                    <label>2</label>Joseph&#xA0;J.&#xA0;Zilber&#xA0;School&#xA0;of&#xA0;Public&#xA0;Health, University&#xA0;of&#xA0;Wisconsin, Milwaukee, WI, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>20</day>
                <month>6</month><year>2022</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#xA9; 2022 Florez-Garcia VA</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport29495" related-article-type="peer-reviewed-article" xlink:href="10.12688/openreseurope.14280.1"/>
            <custom-meta-group>
                <custom-meta>
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        </front-stub>
        <body>
            <p>General feedback: 
                <list list-type="bullet">
                    <list-item>
                        <p>There are many &#x201C;and&#x201D; connections in several sentences, so I highly suggest being simple in sentences for transmitting the ideas.</p>
                    </list-item>
                </list> Summary: 
                <list list-type="bullet">
                    <list-item>
                        <p>The last part of the aim is wordy, so I highly recommend checking the grammar.&#xA0; Also, methods and results should be improved in the same way.</p>
                    </list-item>
                    <list-item>
                        <p>Clarify the meaning of ICTs.</p>
                    </list-item>
                </list> Introduction: 
                <list list-type="bullet">
                    <list-item>
                        <p>Some sentences need to have references that support the statement.&#xA0; Also, several of them are unclear (e.g.: ..This results in the need to re-think social practices and the use of public spaces,&#x2026;)</p>
                    </list-item>
                    <list-item>
                        <p>The sentence &#x201C;Long-term experiences and analysis do not yet exist&#x201D; is not clear. Are you talking about the ICT?</p>
                    </list-item>
                    <list-item>
                        <p>To mention &#x201C;their devices&#x201D; is always confusing.</p>
                    </list-item>
                    <list-item>
                        <p>The aim of this work is not precise; it seems like you are going to account for the number of cases (I'm not sure if it's referring to studies, technologies, etc).</p>
                    </list-item>
                </list> Methods: 
                <list list-type="bullet">
                    <list-item>
                        <p>How can we connect the research strategy's second part with this paper's objective?. The terms (&#x201C;relapse prevention&#x201D; OR &#x201C;substances Use Disorder&#x201D; OR &#x201C;behavioural intervention&#x201D; OR &#x201C;rural treatment&#x201D;OR &#x201C;prevention&#x201D;OR &#x201C;rehabilitation&#x201D;OR &#x201C;harmful habits&#x201D;OR &#x201C;risk reduction behavior&#x201D;) seem to like are outside of the scope of this review.&#xA0; Also, I know you are trying to evaluate something regarding the behavior, but these terms are spread.</p>
                    </list-item>
                    <list-item>
                        <p>I suggest changing the word patients to subjects or individuals because this is not clinical-based research.</p>
                    </list-item>
                    <list-item>
                        <p>The title for table 3 is incomplete.</p>
                    </list-item>
                    <list-item>
                        <p>I'm not sure if annex means supplemental material.</p>
                    </list-item>
                    <list-item>
                        <p>There is no information regarding how the authors analyzed the results.</p>
                    </list-item>
                    <list-item>
                        <p>I recommend checking the spelling in the search terms (e.g, behavioral is incorrect)</p>
                    </list-item>
                </list> Results: 
                <list list-type="bullet">
                    <list-item>
                        <p>In figure 1, you mentioned that a meta-analysis was done, but it is not true.</p>
                    </list-item>
                    <list-item>
                        <p>Figures must be entitled according to appearing order.&#xA0; Thus, current figure 3 actually is figure 2.&#xA0; Otherwise, please describe the figure 2 in the results before the current figure 3.</p>
                    </list-item>
                    <list-item>
                        <p>I highly recommend improving the results.&#xA0; You included 180 papers to extract more information about the entire profile and even grouped papers (e.g., type of technologies, devices used, areas for use, etc.).&#xA0; Also, I highly recommend changing the visualization style in the figures.</p>
                    </list-item>
                    <list-item>
                        <p>You have 180 articles included, but it is not clear to know exactly which articles you included because they are not even in references.&#xA0; Thus, I recommend a) including all the articles in the references and 2) improving the visualization of all of these in the results section (could be in tables instead to mentioned them in brackets)</p>
                    </list-item>
                </list> Discussion: 
                <list list-type="bullet">
                    <list-item>
                        <p>I just realized that this section included several results than an analysis. I would recommend to re-locate the information.</p>
                    </list-item>
                    <list-item>
                        <p>I highly recommend improving this section by comparing, contrasting, providing hypotheses, etc.&#xA0; A more significant number of references in this section will demonstrate that the authors know the state of the art of this research and analysis itself.</p>
                    </list-item>
                </list>
            </p>
            <p>Are the rationale for, and objectives of, the Systematic Review clearly stated?</p>
            <p>Partly</p>
            <p>Is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are sufficient details of the methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results presented in the review?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Epidemiology, Public Health</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment3437-29495">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>RAMOS</surname>
                            <given-names>Victoria</given-names>
                        </name>
                        <aff>Instituto de Salud Carlos III, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>6</day>
                    <month>7</month><year>2022</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thank you very much for your contributions, which have mostly been included in the new version. The language review has been done by a native English speaker. Some clarifications have been included, tables and order of figures have been revised taking into account your comments.</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report29496">
        <front-stub>
            <article-id pub-id-type="doi">10.21956/openreseurope.15405.r29496</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Fernandez-Martin</surname>
                        <given-names>Juan</given-names>
                    </name>
                    <xref ref-type="aff" rid="r29496a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r29496a1">
                    <label>1</label>Department&#xA0;of&#xA0;Computer&#xA0;Science&#xA0;and&#xA0;Artificial&#xA0;Intelligence,&#xA0;School&#xA0;of&#xA0;Technology&#xA0;and&#xA0;Telecommunications&#xA0;Engineering, University&#xA0;of&#xA0;Granada, Granada, Spain</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>20</day>
                <month>6</month><year>2022</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#xA9; 2022 Fernandez-Martin J</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport29496" related-article-type="peer-reviewed-article" xlink:href="10.12688/openreseurope.14280.1"/>
            <custom-meta-group>
                <custom-meta>
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                </custom-meta>
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        </front-stub>
        <body>
            <p>
                <bold>Key words</bold>
            </p>
            <p> The authors could add &#x2018;telemedicine&#x2019; to the key words, because it is an important element and they have used it in the search strategy.</p>
            <p> </p>
            <p> 
                <bold>Introduction </bold>
            </p>
            <p> A better and concise definition of co-creative methodology is needed.</p>
            <p> </p>
            <p> &#x201C;The intertwining of real and virtual worlds also opens up new ways of advancing knowledge, gathering and interpreting data, and disseminating the adquired knowledge&#x201D;</p>
            <p> </p>
            <p> At this point, the authors could review the recent development of the concept &#x2018;metaverse&#x2019;.</p>
            <p> </p>
            <p> 
                <bold>Results.</bold>
            </p>
            <p> The following sentence in the quality evaluation paragraph is not clear enough:</p>
            <p> &#x2018;This is due to the fact that there is a lack of published papers about co-creation methodology where most of the papers included only partially cover the subject matter, and in some of the cases, the sample size was not large enough.'</p>
            <p> </p>
            <p> 
                <bold>Tables</bold>
            </p>
            <p> Table 1. The ending publications date must be specified.</p>
            <p> </p>
            <p> Table 1. Questioner or questionnaire?</p>
            <p> </p>
            <p> 
                <bold>Annex 1.</bold>
            </p>
            <p> The annex one is missing. It should be provided by the authors.</p>
            <p> </p>
            <p> 
                <bold>General comments</bold>
            </p>
            <p> The English writing needs slight improvements. Example, in the abstract: &#x2018;prevention of risky habbits are made manually&#x2019;; better, &#x2018; prevention of risky 
                <bold>habits were</bold> made manually&#x2019;. In the introduction, &#x2018; This result in the need to&#x2019;: &#x2018;this 
                <bold>results</bold> in the need to&#x2019;. Table one, &#x2018;on lime games&#x2019;: on 
                <bold>line</bold> games.</p>
            <p> &#x2018;In one hand&#x2019;: 
                <bold>on the</bold> one hand.</p>
            <p> </p>
            <p> An increasing interest in the design and assessment of care models with a high technological content (
                <bold>and)</bold> that provide psychological therapy to young subjects using the technologies and tools that 
                <bold>they</bold> are familiar with.</p>
            <p> </p>
            <p> 
                <bold>Conclusion</bold>
            </p>
            <p> This paper aims to review published cases of co-creation methodology on the use of smart technologies in public spaces, new forms of social interactions, practices, and communication between isolated and dispersed communities, and the existence of a digital divide. This article is somehow too ambitious because its scope includes behaviour, abuse of substances, online gaming and education. Even so, it is interesting for professionals working in these areas and searching to learn about the possibilities of new technologies in health promotion. More studies in those specific areas are needed.</p>
            <p>Are the rationale for, and objectives of, the Systematic Review clearly stated?</p>
            <p>Yes</p>
            <p>Is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are sufficient details of the methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results presented in the review?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Health care quality assurance. Research and innovation planning and management. e-Health. Preventive medicine and public health.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment3438-29496">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>RAMOS</surname>
                            <given-names>Victoria</given-names>
                        </name>
                        <aff>Instituto de Salud Carlos III, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>6</day>
                    <month>7</month><year>2022</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thank you very much for your contributions, which have mostly been included in the new version. The language review has been done by a native English speaker. Some clarifications have been included, tables and order of figures have been revised taking into account your comments.</p>
            </body>
        </sub-article>
        <sub-article article-type="response" id="comment3449-29496">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Fern&#xE1;ndez Mart&#xED;n</surname>
                            <given-names>Juan</given-names>
                        </name>
                        <aff>SESCAM, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>25</day>
                    <month>7</month><year>2022</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thank you very much, Victoria. Your article is very interesting. Congratulations. Best regards. Juan Fern&#xE1;ndez</p>
            </body>
        </sub-article>
    </sub-article>
</article>